Calcium Channel Antagonist

Calcium Channel Antagonists (101):

Cat. No.	Product Name	Effect	Purity

HY-B0284

Nifedipine	Antagonist	99.90%
Nifedipine (BAY-a-1040) is a potent calcium channel blocker and agent of choice for cardiac insufficiencies.

HY-14276A

Gallopamil hydrochloride	Antagonist	99.15%
Gallopamil hydrochloride (Methoxyverapamil hydrochloride), a methoxy derivative of Verapamil, is a phenylalkylamine calcium antagonist. Gallopamil hydrochloride inhibits acid secretion in a concentration-dependent manner with an IC₅₀ of 10.9 μM. Gallopamil hydrochloride is a potent antiarrhythmic and vasodilator agent.

HY-103315

Bepridil hydrochloride	Antagonist	99.86%
Bepridil hydrochloride (CERM 1978) is a calcium channel blocker, with antianginal activity.

HY-Z0816

Dehydronitrosonisoldipine	Antagonist	≥98.0%
Dehydronitrosonisoldipine, a derivative of Nisoldipine (HY-17402), is an irreversible and cell-permeant sterile alpha and TIR motif-containing 1 (SARM1) inhibitor. Dehydronitrosonisoldipine acts mainly by blocking SARM1 activation but not its enzymatic activities. Dehydronitrosonisoldipine inhibits SARM1 and axon degenration (AxD) by covalently modifying cysteines, also inhibits the Vincristine-activated cADPR production in neurons. Dehydronitrosonisoldipine can be used for researching neurodegenerative disorders.

HY-17436

Clevidipine	Antagonist	99.88%
Clevidipine is a short-acting dihydropyridine calcium channel antagonist (IC50= 7.1 nM, V(H) = -40 mV ).

HY-111828

TTA-A2	Antagonist	≥99.0%
TTA-A2 is a potent, selective and orally active t-type voltage gated calcium channel antagonist with reduced pregnane X receptor (PXR) activation. TTA-A2 is equally potent against the Cav3.1 (a₁G) and Cav3.2 (a₁H) channels with IC₅₀ values of 89 nM and 92 nM, respectively, at -80 and -100 mV holding potentials. TTA-A2 can be used for the research of a variety of human neurological diseases, including sleep disorders and epilepsy.

HY-B0549A

Flavoxate hydrochloride	Antagonist	99.85%
Flavoxate hydrochloride is a potent and competitive phosphodiesterase (PDE) inhibitor. Flavoxate hydrochloride is an antispasmodic agent and muscarinic mAChR antagonist. Flavoxate hydrochloride shows moderate calcium antagonistic activity and local anesthetic effect. Flavoxate hydrochloride can be used for the research of overactive bladder (OAB) and lower urinary tract infections.

HY-N6066

Praeruptorin E	Antagonist	99.83%
Praeruptorin E is a main bioactive constituent of Peucedanum praeruptorum (also known as Bai-Hua Qian Hu). Praeruptorin C is a calcium antagonist with pD₂^′ value of 5.2.

HY-116408A

Propiverine hydrochloride	Antagonist	99.89%
Propiverine hydrochloride is a bladder spasmolytic with calcium antagonistic and anticholinergic properties. Propiverine hydrochloride can be used for the research of overactive blaqdder and urinary incontinence.

HY-103318

PD173212	Antagonist	99.88%
PD173212 is a selective N-type voltage sensitive calcium channel (VSCC) blocker, with an IC₅₀ of 36 nM in IMR-32 assays.

HY-14284

Nilvadipine	Antagonist	99.96%
Nilvadipine is a potent calcium channel antagonist, and the IC₅₀ value is around 0.1 nM.

HY-10388

TTA-Q6	Antagonist	99.97%
TTA-Q6 is a selective T-type Ca²⁺ channel antagonist, which can be used in the research of neurological disease.

HY-U00212

Aranidipine	Antagonist	99.12%
Aranidipine (MPC1304) is a Ca²⁺ channel antagonist with potent and long-lasting antihypertensive effects.

HY-N0215S5

L-Phenylalanine-¹⁵N	Antagonist	98.10%
L-Phenylalanine-¹⁵N is the ¹⁵N-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].

HY-N0079

Praeruptorin C	Antagonist	99.78%
Praeruptorin C is a main bioactive constituent of Peucedanum praeruptorum (also known as Bai-Hua Qian Hu). Praeruptorin C is a calcium antagonist with pD₂^′ value of 5.7.

HY-U00137

YS-201	Antagonist	99.70%
YS-201 is a dihydropyridine-type calcium channel antagonist. YS-201 has the potential for angina pectoris and hypertension treatment.

HY-101390

(+)-Niguldipine hydrochloride	Antagonist	98.06%
(+)-Niguldipine hydrochloride is an antagonist for calcium channel. (+)-Niguldipine hydrochloride produces vasodilation by blocking calcium channels and reducing the transmembrane influx of calcium ions. (+)-Niguldipine hydrochloride inhibits U-46619 (HY-108566)-induced coronary vasoconstriction in guinea pig Langendorff heart with pID₅₀ of 11.37, binds to calcium channel on guinea pig skeletal muscle membrane with K_i of 9.75, and lowers the blood pressure in spontaneously hypertensive rat with pED₃₀ of 7.1. (+)-Niguldipine hydrochloride ameliorates cardiovascular diseases such as hypertension, angina pectoris and arrhythmias.

HY-14276

Gallopamil	Antagonist	≥98.0%
Gallopamil (Methoxyverapamil), a methoxy derivative of Verapamil, is a phenylalkylamine calcium antagonist. Gallopamil inhibits acid secretion in a concentration-dependent manner with an IC₅₀ of 10.9 μM. Gallopamil is a potent antiarrhythmic and vasodilator agent.

HY-16489A

Terodiline hydrochloride	Antagonist	99.78%
Terodiline hydrochloride is an M1-selective muscarinic receptor (mAChR) antagonist with K_bs of 15, 160, 280, and 198 nM in rabbit vas deferens (M1), atria (M2), bladder (M3) and ileal muscle (M3), respectively. Terodiline hydrochloride also is a Ca²⁺ blocker. Terodiline hydrochloride acts as a treatment for urinary frequency and urge incontinence.

HY-U00044

Anipamil	Antagonist	99.34%
Anipamil is a long-acting calcium channel blocker, used for the treatment of cardiovascular disease.

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